Infertility improved by etanercept in ankylosing spondylitis
نویسندگان
چکیده
The effect of TNF-α and TNF-α antagonists on semen quality in men is controversial. TNF-α levels are usually low in seminal plasma, but they tend to increase in inflammatory and infectious diseases. Etanercept is a highly-specific antagonist of TNF-α. In this report, we describe the development of pregnancy in a couple with a previously infertile husband, who received etanercept for ankylosing spondylitis.
منابع مشابه
Outcomes of a multicentre randomised clinical trial of etanercept to treat ankylosing spondylitis.
OBJECTIVE A double blind, randomised, placebo controlled study to evaluate the safety and efficacy of etanercept to treat adult patients with ankylosing spondylitis (AS). METHODS Adult patients with AS at 14 European sites were randomly assigned to 25 mg injections of etanercept or placebo twice weekly for 12 weeks. The primary efficacy end point was an improvement of at least 20% in patient ...
متن کاملSustained durability and tolerability of etanercept in ankylosing spondylitis for 96 weeks.
OBJECTIVE To evaluate the continued safety and durability of clinical response in patients with ankylosing spondylitis receiving etanercept. METHODS 277 patients who had participated in a previous randomised, double blind, placebo controlled 24 week trial were eligible to continue in this open label extension study. All patients who enrolled in the open label extension (n = 257) received subc...
متن کاملImprovement in patient-reported outcomes for patients with ankylosing spondylitis treated with etanercept 50 mg once-weekly and 25 mg twice-weekly.
OBJECTIVES The objective of this study was to assess the humanistic impact of ankylosing spondylitis (AS), and compare the effect of etanercept 50 mg once-weekly (QW), etanercept 25 mg twice-weekly (BIW) and placebo on patient-reported outcomes (PROs). METHODS In a 12-week, double-blind, placebo-controlled multicenter study, 356 patients with active AS received etanercept 50 mg QW, etanercept...
متن کاملIs Etanercept A Safe and Effective Treatment For Ankylosing Spondylitis?
Objective: The objective of this selective EBM review is to determine whether or not etanercept is a safe and effective treatment for ankylosing spondylitis (AS). Study Design: Review of three English language randomized control trials published in 2007, 2008, and 2010. Data Sources: Two double-blind placebo-controlled randomized controlled trials and one placebo-controlled randomized control t...
متن کاملPustular eruption induced by etanercept in a patient with ankylosing spondylitis: a rare side effect
Etanercept is a tumor necrosis factor alpha (TNF-a) antagonist with anti-inflammatory effects. It is used in the treatment of dermatologic and rheumatologic diseases such as rheumatoid arthritis, polyarticular juvenile rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. However, etanercept has various cutaneous and systemic side effects. Herein, we report a case of generalized...
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